Understanding the dynamic relation between wastewater SARS-CoV-2 signal and clinical metrics throughout the pandemicArticle Published on 2022-12-202022-11-16 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 변종, [키워드] Alpha variant clinical testing Community complementary COVID-19 COVID-19 disease COVID-19 incidence deaths Delta VOC disease disease incidence Effectiveness expected Hospital admissions ICU admissions immunization incidence Infection Laboratory positive cases Metrics moderate omicron pandemic Population positive SARS-CoV-2 shown Spread Surveillance understanding vaccination vaccination rate Vaccine virulence VoC waned wastewater weakened widespread wildtype WWS. [DOI] 10.1016/j.scitotenv.2022.158458 PMC 바로가기
Understanding the impact of rapid antigen tests on SARS-CoV-2 transmission in the fifth wave of COVID-19 in Hong Kong in early 20222022년 초 홍콩에서 COVID-19의 5번째 물결에서 SARS-CoV-2 전파에 대한 신속한 항원 검사의 영향 이해Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, [키워드] addition Analysis Antigen case fatality ratio confirmed case confirmed cases COVID-19 decrease disease transmission effective examined Government highlight home quarantine Hong Kong implementation mass measure omicron outbreak rapid antigen test Rapid antigen tests Region Reproduction number rising SARS-CoV-2 SARS-CoV-2 transmission suggested superspreading. the disease understanding variant of SARS-CoV-2 [DOI] 10.1080/22221751.2022.2076616 PMC 바로가기 [Article Type] Article
Low BALF CD4 T cells count is associated with extubation failure and mortality in critically ill covid-19 pneumonia낮은 BALF CD4 T 세포 수는 중환자의 covid-19 폐렴에서 발관 실패 및 사망률과 관련이 있습니다Article Published on 2022-12-012022-09-11 Journal: Annals of Medicine [Category] 바이오마커, 진단, [키워드] affected alveolar alveolar macrophage analysed average BALF BALF CD4 T-cells count baseline Biomarker bivariate analysis Bronchoalveolar lavage fluid caspase caspase-3 cause CD4 CD4 T cell CD4 T-cell Characteristics clinical Clinical characteristics conducted COVID-19 COVID-19 patients COVID-19 pneumonia COVID-19 pneumonia patient COVID-19 pneumonia patients Critically ill critically ill COVID-19 patients Critically ill COVID-19 pneumonia D-dimer D-dimer level eight enrolled extubation failure. groups help IL-17 IL-6 immunopathology IMPROVE Indonesia intubation Invasive mechanical ventilation Laboratory lung Macrophage material Mortality no significant difference no significant differences outcome Patient performed Pneumonia profile Referral reported right lung severe pneumonia severity significant differences significantly survived T-cells Tertiary Tregs understanding was performed were measured [DOI] 10.1080/07853890.2022.2095012 PMC 바로가기 [Article Type] Article
Investigating public awareness, prevailing attitudes and perceptions towards domestic violence and abuse in the United Kingdom: a qualitative studyArticle Published on 2022-11-082022-11-15 Journal: BMC Public Health [Category] 치료제, [키워드] Abuse analysed Analysis Care children Community community setting concerning conducted contributing to COVID-19 COVID-19 pandemic detect develop domestic violence effective effective interventions event Factor Health help highlighting Impact instance Intervention interventions investigated lockdowns mechanism media Raising awareness Rapid Rapid screening tools. reduce Research rising Support targeted intervention Topic transcribed understanding Violence [DOI] 10.1186/s12889-022-14426-9 PMC 바로가기
Antigenic mapping reveals sites of vulnerability on α-HCoV spike proteinArticle Published on 2022-11-042022-11-15 Journal: Communications Biology [Category] SARS, 진단, [키워드] antigenic appear characterized conserved distal domain dominant effective epitope Epitopes feasibility HCoV-229E HCoV-NL63 highlight human coronavirus imperative N-terminal domain Neutralizing neutralizing antibody panel of antibody Protein RBD Receptor binding domain receptor binding site recognize representing reveal S protein S proteins similarity spike Spike protein subset the SARS-CoV-2 understanding Vaccine design Vaccine development [DOI] 10.1038/s42003-022-04160-8 PMC 바로가기
Understanding and combating COVID-19 using the biology and chemistry of SARS-CoV-2Article Published on 2022-11-012022-11-15 Journal: Bioprocess and biosystems engineering [Category] SARS, 치료기술, [키워드] ACE acute respiratory syndrome angiotensin-converting enzyme 2 Angiotensin-converting enzyme 2 (ACE2) Asymptomatic binding caused combating contributed coronavirus coronavirus disease COVID-19 enzyme high affinity host receptor hydrophobic Infection Interaction lead to fatality Like molnupiravir Mutation Nanotechnology omicron pandemic pathogenic viruses PAXLOVID™ provide quercetin Remdesivir responsible SARS-CoV-2 spike glycoprotein suggested Transmissibility understanding vaccine. Vaccines viability virus [DOI] 10.1007/s00449-022-02788-8 PMC 바로가기
Biochemical Characterization of Emerging SARS-CoV-2 Nsp15 Endoribonuclease VariantsArticle Published on 2022-10-302022-11-16 Journal: Journal of Molecular Biology [Category] COVID19(2023년), SARS, 변종, [키워드] Affect analysis analyzed biochemically bioinformatics catalytic caused changed characterization characterized cleavage Combination conserved coronavirus Coronaviruses Course COVID-19 pandemic domain drug design effort endoribonuclease endoribonuclease. EndoU evade Evolution facilitate Genome help Host immune response in vivo inactive increase in innate immune response middle monomeric Mutation N-terminal nonstructural proteins novel coronavirus SARS-CoV-2 Nsp15 oligomerization pandemic Patient prevalent Protein residue RNA SARS-CoV-2 SARS-CoV-2 sequence Sequencing Transcription triggering understanding variant viral genome Viral protein viral replication virus wild type [DOI] 10.1016/j.jmb.2022.167796 PMC 바로가기
Immune response after COVID-19 vaccination among patients with chronic kidney disease and kidney transplantArticle Published on 2022-10-262022-11-15 Journal: Vaccine [Category] COVID19(2023년), SARS, 진단, [키워드] adverse event Affect analyzed Anti-spike RBD IgG antibody antibody response against Blood Group Breakthrough infection cellular response ChAdOx1 nCoV-19 ChAdOx1 nCoV-19 vaccine chronic Chronic kidney disease CKD comparable Control controls Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) COVID-19 COVID-19 vaccination exhibited first dose group healthy controls Hemodialysis humoral Illness severity immune response immunological responses Inactivated vaccine incidence of COVID-19 individual injection kidney kidney transplant less lowest neutralizing antibody occurred outcome Patient patient group Peritoneal dialysis Protective RBD robust SARS-CoV-2 vaccine secondary single dose suggested T cell response the S protein the vaccine total population understanding vaccination Vaccine vaccine. virus neutralization test [DOI] 10.1016/j.vaccine.2022.09.067 PMC 바로가기
Understanding the immunological landscape of England during SARS-CoV2 Omicron variant waveArticle Published on 2022-10-142022-11-16 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, [키워드] B.1.1.529 booster dose Cell country defined dose Endemic England estimate Evidence expected groups immune evasion Immunity immunological increased risk indicated Infection iterative less National Older age omicron Population proportion public health SARS-CoV2 Spread understanding Vaccine variant variants virus [DOI] 10.1371/journal.pone.0264870 PMC 바로가기
Comparative Analysis of Antibody Titers against the Spike Protein of SARS-CoV-2 Variants in Infected Patient Cohorts and Diverse Vaccination RegimesArticle Published on 2022-10-132022-11-15 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] accompanied antibody Antibody Response AstraZeneca B cell benefit booster vaccination cells Comparative courses COVID-19 COVID-19 pandemic Critical critical COVID-19 patients exceeded follicular Frequency Infection Inflammation Inflammatory response Johnson & Johnson long-COVID Lymphocytes Mild Moderna mRNA vaccine neutralizing antibody patients patients who survived Pfizer-BioNTech recommendation reduced regime SARS-CoV-2 SARS-CoV-2 patient severe COVID-19 disease the SARS-CoV-2 virus the Spike titer understanding vaccination Vaccination strategy vaccination. Vaccine [DOI] 10.3390/ijms232012231 PMC 바로가기